DR4 rabbit pAb
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Synonyms
Gene ID
8797
UniProt
O00220
Cellular Locus
Cell membrane ; Single-pass type I membrane protein. Membrane raft. Cytoplasm, cytosol. Palmitoylation is required for association with membranes..
Host
Rabbit
Species Reactivity
Human,Monkey
Reactivity
Human; Monkey
Immunogen
The antiserum was produced against synthesized peptide derived from human TNFRSF10A. AA range:401-450
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IF, ELISA
Validated Applications
WB,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
50kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES2198-1.pdf
Observed Molecular Weight
50 kD
Subcellular Location
Other Product Names
Gene ID (Human)
8797
SwissProt (Human)
O00220
Available Sizes
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