Dok-3 rabbit pAb

Domain: PTB domain mediates receptor interaction. function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL function. PTM: Constitutively tyrosine-phosphorylated. PTM: On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase. similarity: Belongs to the DOK family. Type A subfamily. similarity: Contains 1 IRS-type PTB domain. similarity: Contains 1 PH domain. subunit: On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP. tissue specificity: Expressed in spleen.