DHRS4 rabbit pAb

Catalytic activity: R-CHOH-R' + NADP (+) = R-CO-R' + NADPH. function: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones. miscellaneous: Inhibited by kaempferol, quercetin, genistein and myristic acid. similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. subcellular location: Isoform 1 is peroxisomal, while isoform 4 is not. subunit: Homotetramer. tissue specificity: Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoforms 5 and 6 are expressed in a few neoplastic cervical tissues.