Dbf4 rabbit pAb

Function: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. induction: Induced in G1 phase at low level, increased during G1-S phase and remain high during S and G2-M phase. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 DBF4-type zinc finger. similarity: Contains 2 BRCT domains. subunit: Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2L, ORC4L and ORC6L. tissue specificity: Highly expressed in testis and thymus. Expressed also in most cancer cells lines.