Cytokeratin 10 rabbit pAb

This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

P13645

Swiss Prot

P13645

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human Keratin 10. AA range:136-185

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight

59kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

59kD

Fragment

IgG

Subcellular Location

Secreted, extracellular space . Cell surface . Localized on the surface of desquamated nasal epithelial cells (PubMed:12427098) . Localized on the surface of lung cell lines (PubMed:19627498) . .