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Quinagolide (hydrochloride)

Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamine D2 receptor agonist. Quinagolide hydrochloride is an inhibitor of prolactin. Quinagolide hydrochloride down-regulates AKT levels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research of cancer[1][2].

Product Specifications

CAS Number

94424-50-7

Product Name Alternative

CV205-502 hydrochloride

UNSPSC

12352005

Target

Akt; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Quinagolide-hydrochloride.html

Purity

99.69

Solubility

DMSO : 3.85 mg/mL (ultrasonic)

Smiles

OC1=C2C(C[C@](N(CCC)C[C@@H](NS(N(CC)CC)(=O)=O)C3)([H])[C@@]3([H])C2)=CC=C1.Cl

Molecular Formula

C20H34ClN3O3S

Molecular Weight

432.02

References & Citations

[1]Trouillas J, et al. Inhibitory effects of the dopamine agonists quinagolide (CV 205-502) and bromocriptine on prolactin secretion and growth of SMtTW pituitary tumors in the rat. Endocrinology. 1994 Jan;134 (1) :401-10.|[2]Iampietro C, et al. Quinagolide Treatment Reduces Invasive and Angiogenic Properties of Endometrial Mesenchymal Stromal Cells. Int J Mol Sci. 2022 Feb 4;23 (3) :1775.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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