Cdc42EP5 rabbit pAb
Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013],
Product Specifications
Background
Synonyms
CDC42EP5; BORG3; CEP5; Cdc42 effector protein 5; Binder of Rho GTPases 3
Gene ID
148170
UniProt
Q6NZY7
Cellular Locus
Endomembrane system ; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human BORG3. AA range:1-50
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
22kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES1932-1.pdf
Observed Molecular Weight
22 kD
Subcellular Location
Endomembrane system ; Peripheral membrane protein . Cytoplasm, cytoskeleton .
Other Product Names
CDC42EP5; BORG3; CEP5; Cdc42 effector protein 5; Binder of Rho GTPases 3
Gene ID (Human)
148170
SwissProt (Human)
Q6NZY7
Available Sizes
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