CD284 rabbit pAb
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
Product Specifications
Background
Synonyms
TLR4; Toll-like receptor 4; hToll; CD antigen CD284
Gene ID
7099
UniProt
O00206
Cellular Locus
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human CD284. AA range:392-441
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
IF, WB, IHC, ELISA
Validated Applications
IF,WB,IHC,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
95kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES1902-1.pdf
Observed Molecular Weight
95 kD
Subcellular Location
Other Product Names
TLR4; Toll-like receptor 4; hToll; CD antigen CD284
Gene ID (Human)
7099
SwissProt (Human)
O00206
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
