CD137L rabbit pAb
The protein encoded by this gene is a Cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane Cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This Cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This Cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This Cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. [provided b
Product Specifications
Background
Product Name Alternative
TNFSF9; Tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL
UniProt
P41273
Swiss Prot
P41273
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human TNFSF9. AA range:31-80
Target
CD137L
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
23kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
23kD
Fragment
IgG
Subcellular Location
Membrane; Single-pass type II membrane protein.
Other Product Names
TNFSF9; Tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL
Gene ID (Human)
8744
Available Sizes
Frequently Asked Questions
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