CD137L rabbit pAb

The protein encoded by this gene is a Cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane Cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This Cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This Cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This Cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. [provided b