Cables1 rabbit pAb

This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],

Product Specifications

Background

This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127) .Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

UniProt

Q8TDN4

Swiss Prot

Q8TDN4

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human Ik3-1. AA range:561-610

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight

67kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

67kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm . Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity) . .