Isoxicam

Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis[1]. Isoxicam is a nonselective inhibitor of COX-1 and COX-2[2].

Product Specifications

CAS Number

[34552-84-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/isoxicam.html

Purity

99.83

Solubility

DMSO : 3.33 mg/mL (ultrasonic)

Smiles

O=C(C1=C(O)C2=CC=CC=C2S(N1C)(=O)=O)NC3=NOC(C)=C3

Molecular Formula

C14H13N3O5S

Molecular Weight

335.34

Precautions

H315, H319, H335

References & Citations

[1]DiPasquale G, et al. The antiinflammatory properties of isoxicam (4-hydroxy-2methyl-N- (5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) . Agents Actions. 1975 Aug;5 (3) :256-63.|[2]Xu S, et al. Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network. J Biol Chem. 2014 Mar 7;289 (10) :6799-808.