Isoxicam
Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis[1]. Isoxicam is a nonselective inhibitor of COX-1 and COX-2[2].
Product Specifications
CAS Number
34552-84-6
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/isoxicam.html
Purity
99.83
Solubility
DMSO : 3.33 mg/mL (ultrasonic)
Smiles
O=C(C1=C(O)C2=CC=CC=C2S(N1C)(=O)=O)NC3=NOC(C)=C3
Molecular Formula
C14H13N3O5S
Molecular Weight
335.34
Precautions
H315, H319, H335
References & Citations
[1]DiPasquale G, et al. The antiinflammatory properties of isoxicam (4-hydroxy-2methyl-N- (5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) . Agents Actions. 1975 Aug;5 (3) :256-63.|[2]Xu S, et al. Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network. J Biol Chem. 2014 Mar 7;289 (10) :6799-808.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-1; COX-2
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