AR-β1 rabbit pAb

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008],

Product Specifications

Background

Product Name Alternative

ADRB1; ADRB1R; B1AR; Beta-1 adrenergic receptor; Beta-1 adrenoreceptor; Beta-1 adrenoceptor

UniProt

P08588

Swiss Prot

P08588

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human ADRB1. AA range:281-330

Target

AR-β1

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

51kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

51kD

Fragment

IgG

Subcellular Location

Cell membrane ; Multi-pass membrane protein . Early endosome. Colocalizes with RAPGEF2 at the plasma membrane (By similarity) . Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. .