EPI-743

EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione[1][2].

Product Specifications

CAS Number

[1213269-98-7]

Product Name Alternative

α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Ferroptosis; Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/epi-743.html

Purity

98.60

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(CC[C@](C)(O)CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)C(C(C)=C1C)=O

Molecular Formula

C29H44O3

Molecular Weight

440.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Kouga T, et al. Japanese Leigh syndrome case treated with EPI-743. Brain Dev. 2018 Feb;40 (2) :145-149. Brain Dev. 2018 Feb;40 (2) :145-149.|[2]Avula S, et al. Treatment of Mitochondrial Disorders. Curr Treat Options Neurol. 2014. 16:292.|[3]Kahn-Kirby AH, et al. Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy. PLoS One. 2019 Mar 28;14 (3) :e0214250.