EPI-743
Product Specifications
UNSPSC Description
EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione[1][2].
Target Antigen
Ferroptosis; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/epi-743.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(CC[C@](C)(O)CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)C(C(C)=C1C)=O
Molecular Weight
440.66
References & Citations
[1]Kouga T, et al. Japanese Leigh syndrome case treated with EPI-743. Brain Dev. 2018 Feb;40(2):145-149. Brain Dev. 2018 Feb;40(2):145-149.|[2]Avula S, et al. Treatment of Mitochondrial Disorders. Curr Treat Options Neurol. 2014. 16:292.|[3]Kahn-Kirby AH, et al. Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy. PLoS One. 2019 Mar 28;14(3):e0214250.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16772/EPI-743-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16772/EPI-743-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
1213269-98-7
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Monoclonal S100A13 Antibody (184) [Alexa Fluor 488]](https://cdn.genprice.uk/genprice/genprice5.png)
RC221420L1V 200 µL
DR3 (TNFRSF25) (NM_148965) Human Tagged ORF Clone Lentiviral Particle
Ask
View Details