EPI-743
EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione[1][2].
Product Specifications
CAS Number
1213269-98-7
Product Name Alternative
α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Ferroptosis; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/epi-743.html
Purity
98.60
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(CC[C@](C)(O)CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)C(C(C)=C1C)=O
Molecular Formula
C29H44O3
Molecular Weight
440.66
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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