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Tensin-1 (phospho Tyr1326) rabbit pAb

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],

Product Specifications

Background

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Product Name Alternative

TNS1; TNS; Tensin-1

UniProt

Q9HBL0

Swiss Prot

Q9HBL0

Reactivity

Human; Mouse

Immunogen

Synthesized phospho-peptide around the phosphorylation site of human Tensin-1 (phospho Tyr1326)

Target

Tensin-1

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

185kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

185kD

Fragment

IgG

Subcellular Location

Cell surface . Cell junction, focal adhesion . Cytoplasm, cytoskeleton . Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.

Other Product Names

TNS1; TNS; Tensin-1

Gene ID (Human)

7145

Available Sizes

Curated Selection

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