C-Myc (phospho Ser62) rabbit pAb
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008],
Product Specifications
Background
UniProt
P01106
Swiss Prot
P01106
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Myc around the phosphorylation site of Ser62. AA range:31-80
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Molecular Weight
50,(also ~60KD in some samples)
Storage Conditions
-20°C/1 year
Observed Molecular Weight
50, (also ~60KD in some samples)
Fragment
IgG
Subcellular Location
Nucleus, nucleoplasm . Nucleus, nucleolus .
Other Product Names
MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
Gene ID (Human)
4609
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
