Stat2 (phospho Tyr690) rabbit pAb
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],
Product Specifications
Background
UniProt
P52630
Swiss Prot
P52630
Reactivity
Human; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human STAT2 around the phosphorylation site of Tyr690. AA range:656-705
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
113kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
113kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Translocated into the nucleus upon activation by IFN-alpha/beta. .
Other Product Names
STAT2; Signal transducer and activator of transcription 2; p113
Gene ID (Human)
6773
Available Sizes
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