AMPKα1/2 (phospho Thr183/172) rabbit pAb
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Product Name Alternative
UniProt
Q13131/P54646
Swiss Prot
Q13131/P54646
Reactivity
Human; Mouse; Rat; Monkey; Pig
Immunogen
The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Target
AMPKα1/2
Clonality
Polyclonal
Source
Rabbit
Applications
IF; WB; IHC; ELISA
Concentration
1 mg/ml
Dilution
IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
63kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
63kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . In response to stress, recruited by p53/TP53 to specific promoters. .
Other Product Names
Gene ID (Human)
5562/5563
Available Sizes
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