Stat6 (phospho Thr645) rabbit pAb
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010],
Product Specifications
Background
Product Name Alternative
STAT6; Signal transducer and activator of transcription 6; IL-4 Stat
UniProt
P42226
Swiss Prot
P42226
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human STAT6 around the phosphorylation site of Thr645. AA range:612-661
Target
Stat6
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; IP; ELISA
Concentration
1 mg/ml
Dilution
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
Other Product Names
STAT6; Signal transducer and activator of transcription 6; IL-4 Stat
Gene ID (Human)
6778
Available Sizes
Frequently Asked Questions
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