Rb (phospho Ser807) rabbit pAb
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Product Name Alternative
RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
UniProt
P06400
Swiss Prot
P06400
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser807. AA range:781-830
Target
Rb
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
106kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
106kD
Fragment
IgG
Subcellular Location
Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. .
Other Product Names
RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Gene ID (Human)
5925
Available Sizes
Explore Other Products
Browse additional items from our catalog
Human Protein disulfide-isomerase A5, PDIA5 ELISA KIT
SAE2 / UBA2 Recombinant Antibody, AbBy Fluor™ 594 Conjugated
Prl8a8 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
ARP54860_P050 - FBXO22 antibody - middle region (ARP54860_P050)