Hrs (phospho Tyr216) rabbit pAb

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010],

Product Specifications

Background

Product Name Alternative

HGS; HRS; Hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Protein pp110

UniProt

O14964

Swiss Prot

O14964

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized phospho-peptide around the phosphorylation site of human Hrs (phospho Tyr216)

Target

Hrs

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

115kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

115kD

Fragment

IgG

Subcellular Location

Cytoplasm . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome, multivesicular body membrane ; Peripheral membrane protein . Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments. .