Histone H2A.X (phospho Ser139) rabbit pAb
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015],
Product Specifications
Background
Product Name Alternative
H2AFX; H2AX; Histone H2A.x; H2a/x
UniProt
P16104
Swiss Prot
P16104
Reactivity
Human; Mouse; Rat; Hamster
Immunogen
The antiserum was produced against synthesized peptide derived from human Histone H2A.X around the phosphorylation site of Ser139. AA range:94-143
Target
Histone H2A.X
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
15 19kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
15 19kD
Fragment
IgG
Subcellular Location
Nucleus . Chromosome .
Other Product Names
H2AFX; H2AX; Histone H2A.x; H2a/x
Gene ID (Human)
3014
Available Sizes
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