ERK 1/2 (phospho Thr202) rabbit pAb

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

P27361/P28482

Swiss Prot

P27361/P28482

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human p44/42 MAP Kinase around the phosphorylation site of Thr202. AA range:169-218

Clonality

Polyclonal

Source

Rabbit

Applications

IF; WB; IHC; ELISA

Concentration

1 mg/ml

Dilution

IF: 1:50-200 WB 1:500-2000, IHC 1:50-300 IHC 1:50-300

Molecular Weight

44+42kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

44+42kD

Fragment

IgG

Subcellular Location

Cytoplasm . Nucleus. Membrane, caveola . Cell junction, focal adhesion . Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905) . PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (By similarity) . .

Other Product Names

MAPK3; ERK1; PRKM3; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p