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Erbin (phospho Tyr1104) rabbit pAb

This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],

Product Specifications

Background

This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Synonyms

ERBB2IP; ERBIN; KIAA1225; LAP2; Protein LAP2; Densin-180-like protein; Erbb2-interacting protein; Erbin

Gene ID

55914

UniProt

Q96RT1

Cellular Locus

Cell junction, hemidesmosome. Nucleus membrane. Basolateral cell membrane. Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity)..

Host

Rabbit

Species Reactivity

Human,Rat,Mouse,

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized phospho-peptide around the phosphorylation site of human Erbin (phospho Tyr1104)

Clonality

Polyclonal

Isotype

IgG

Source

Rabbit

Applications

WB, ELISA

Validated Applications

WB,ELISA

Stability

-20°C/1 year

Concentration

1 mg/mL

Dilution

Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight

172kD

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES1307-1.pdf

Observed Molecular Weight

172 kD

Subcellular Location

Cell junction, hemidesmosome . Nucleus membrane . Basolateral cell membrane . Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity) . .

Other Product Names

ERBB2IP; ERBIN; KIAA1225; LAP2; Protein LAP2; Densin-180-like protein; Erbb2-interacting protein; Erbin

Gene ID (Human)

55914

SwissProt (Human)

Q96RT1

Available Sizes

Curated Selection

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