Bcl-2 (phospho Ser70) rabbit pAb

BCL2, apoptosis regulator (BCL2) Homo sapiens This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],

Product Specifications

Background

UniProt

P10415

Swiss Prot

P10415

Reactivity

Human; Monkey

Immunogen

The antiserum was produced against synthesized peptide derived from human BCL-2 around the phosphorylation site of Ser70. AA range:41-90

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; IP; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight

26kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

26kD

Fragment

IgG

Subcellular Location

Mitochondrion outer membrane ; Single-pass membrane protein . Nucleus membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein . Cytoplasm .