Hyodeoxycholic acid (sodium)

Hyodeoxycholic acid sodium is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells[1][2].

Product Specifications

CAS Number

[10421-49-5]

Product Name Alternative

HDCA (sodium)

UNSPSC

12352200

Hazard Statement

H302-H315-H319-H335

Target

Endogenous Metabolite; G protein-coupled Bile Acid Receptor 1

Type

Biochemical Assay Reagents

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hyodeoxycholic-acid-sodium.html

Solubility

10 mM in DMSO

Smiles

C[C@@H]([C@H]1CC[C@]2([C@@]3(C[C@@H]([C@@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)[H])O)[H])[H])CCC(O[Na])=O

Molecular Formula

C24H39NaO4

Molecular Weight

414.55

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27;51 (6) :1831-41.|[2]Shih DM, et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep;27 (9) :3805-17.