Ku-70 (Acetyl Lys539) rabbit pAb
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V (D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Synonyms
Gene ID
2547
UniProt
P12956
Cellular Locus
Nucleus. Chromosome.
Host
Rabbit
Species Reactivity
Human,Rat,Mouse,
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized acetyl-peptide derived from the human Ku-70 around the acetylation site of K539.
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
70kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES1107-1.pdf
Observed Molecular Weight
70 kD
Subcellular Location
Nucleus . Chromosome .
Other Product Names
Gene ID (Human)
2547
SwissProt (Human)
P12956
Available Sizes
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