Cleaved-Integrin α6 LC (E942) rabbit pAb
Integrin subunit alpha 6 (ITGA6) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
Product Specifications
Background
Synonyms
ITGA6; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD antigen CD49f
Gene ID
3655
UniProt
P23229
Cellular Locus
Cell membrane ; Single-pass type I membrane protein. Cell membrane ; Lipid-anchor.
Host
Rabbit
Species Reactivity
Human,Rat,Mouse,
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human ITGA6. AA range:923-972
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA
Validated Applications
WB,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
28kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES1063-1.pdf
Observed Molecular Weight
28 kD
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Cell membrane ; Lipid-anchor .
Other Product Names
ITGA6; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD antigen CD49f
Gene ID (Human)
3655
SwissProt (Human)
P23229
Available Sizes
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