Cleaved-Caspase-6 p18 (D179) rabbit pAb
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015],
Product Specifications
Background
Synonyms
CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2
Gene ID
839
UniProt
P55212
Cellular Locus
Cytoplasm. Nucleus.
Host
Rabbit
Species Reactivity
Human,Rat
Reactivity
Human; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Caspase 6. AA range:130-179
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
20+35kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES1004-1.pdf
Observed Molecular Weight
20+35 kD
Subcellular Location
Cytoplasm . Nucleus .
Other Product Names
CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2
Gene ID (Human)
839
SwissProt (Human)
P55212
Available Sizes
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