Cyamemazine

Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity[1][2].

Product Specifications

CAS Number

[3546-03-0]

UNSPSC

12352005

Hazard Statement

H410

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cyamemazine.html

Purity

99.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(C)CC(C)CN1C2=C(C=CC(C#N)=C2)SC3=CC=CC=C31

Molecular Formula

C19H21N3S

Molecular Weight

323.46

Precautions

H410

References & Citations

[1]Bourin M, et al. Preclinical and clinical pharmacology of cyamemazine: anxiolytic effects and prevention of alcohol and benzodiazepine withdrawal syndrome. CNS Drug Rev. 2004 Fall;10 (3) :219-29.|[2] Vendrell-Criado V, et al. Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environment. J Photochem Photobiol B. 2020 Jan;202:111686.