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ATG4c Rabbit pAb

Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. Control of autophagy was largely discovered in yeast and involves proteins encoded by a set of autophagy-related genes (Atg). Formation of autophagic vesicles requires a pair of essential ubiquitin-like conjugation systems, Atg12-Atg5 and Atg8-phosphatidylethanolamine (Atg8-PE), which are widely conserved in eukaryotes. Numerous mammalian counterparts to yeast Atg proteins have been described, including three Atg8 proteins (GATE-16, GABARAP, and LC3) and four Atg4 homologs (Atg4A/autophagin-2, Atg4B/autophagin-1, Atg4C/autophagin-3, and Atg4D/autophagin-4).

Product Specifications

Background

Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. Control of autophagy was largely discovered in yeast and involves proteins encoded by a set of autophagy-related genes (Atg) . Formation of autophagic vesicles requires a pair of essential ubiquitin-like conjugation systems, Atg12-Atg5 and Atg8-phosphatidylethanolamine (Atg8-PE), which are widely conserved in eukaryotes. Numerous mammalian counterparts to yeast Atg proteins have been described, including three Atg8 proteins (GATE-16, GABARAP, and LC3) and four Atg4 homologs (Atg4A/autophagin-2, Atg4B/autophagin-1, Atg4C/autophagin-3, and Atg4D/autophagin-4) .

Synonyms

APG4C, Autl3, Cysteine protease ATG4C antibody

Gene ID

84938

UniProt

Q96DT6

Cellular Locus

Cytoplasm

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Protein

Clonality

Polyclonal

Isotype

IgG

Source

Rabbit

Applications

IHC

Validated Applications

IHC

Stability

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Concentration

1 mg/mL

Dilution

IHC 1:100-200

Molecular Weight

57kDa

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/EA349-1.pdf

Observed Molecular Weight

57 kDa

Subcellular Location

Cytoplasm

Other Product Names

APG4C, Autl3, Cysteine protease ATG4C antibody

Gene ID (Human)

84938

SwissProt (Human)

Q96DT6

Available Sizes

Curated Selection

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