Claudin-2 (8H11) Mouse mAb
The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer . Claudin-2 is expressed primarily in the proximal tubule of the normal mammalian kidney, where it regulates transepithelial ion (e. g. Na+, Cl-) reabsorption . Increased expression of Claudin-2 has been reported in some cancer cell lines , including A549 lung adenocarcinoma cells, where its nuclear distribution was positively associated with enhanced proliferation .
Product Specifications
Background
Gene ID
9075
UniProt
P57739
Cellular Locus
Cell junction,tight junction,Cell membrane
Host
Mouse
Species Reactivity
Human,Rat,Mouse
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic Peptide
Clonality
Monoclonal
Isotype
IgG1
Source
Mouse
Applications
WB, IHC
Validated Applications
WB,IHC
Stability
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Concentration
1 mg/mL
Dilution
WB 1:1,000-2,000 IHC:1;100-1:200
Molecular Weight
25kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/mAb/EM1403-1.pdf
Observed Molecular Weight
25 kDa
Subcellular Location
Cell junction, tight junction, Cell membrane
Gene ID (Human)
9075
SwissProt (Human)
P57739
Available Sizes
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