Acetyl NF kB P65 (K314/K315) (5G11) Mouse mAb
NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection.
Product Specifications
Background
Product Name Alternative
NF kappa B p65, NFKB3, p65, p65 NF kB, RELA, TF65, Transcription Factor p65
UniProt
Q04206
Swiss Prot
Q04206
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic Peptide
Clonality
Monoclonal
Source
Mouse
Applications
IHC
Concentration
1mg/mL
Dilution
IHC 1:100-200
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Molecular Weight
65kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
65kDa
Fragment
IgG1
Subcellular Location
Cytoplasm, Nucleus
Other Product Names
NF kappa B p65, NFKB3, p65, p65 NF kB, RELA, TF65, Transcription Factor p65
Gene ID (Human)
5970
Available Sizes
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