Phospho-MLKL (S358) (6B4) Mouse mAb
Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358.
Product Specifications
Background
Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358.
Product Name Alternative
Mixed lineage kinase domain like protein, FLJ34389
UniProt
Q8NB16
Swiss Prot
Q8NB16
Reactivity
Human
Immunogen
Synthetic Peptide
Clonality
Monoclonal
Source
Mouse
Applications
IHC
Concentration
1mg/mL
Dilution
IHC 1:100-200
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Molecular Weight
54kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
54kDa
Fragment
IgG1
Subcellular Location
Cell membrane, Cytoplasm, Membrane
Other Product Names
Mixed lineage kinase domain like protein, FLJ34389
Gene ID (Human)
197259
Available Sizes
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