AP102

AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA) . AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC50: 0.63 and 0.65 nM, respectively) . AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research[1].

Product Specifications

CAS Number

846569-60-6

UNSPSC

12352209

Target

Somatostatin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ap102.html

Solubility

H2O

Smiles

O=C(N[C@H](C(N[C@H](C(N1)=O)C(C)C)=O)CCCCN)[C@H](NC([C@@H](NC([C@H](CSSC[C@H]1C(N[C@H](C(N)=O)[C@H](O)C)=O)NC([C@H](N)CC(C=C2)=CC(I)=C2N)=O)=O)CC(C=C3)=CC(I)=C3O)=O)CC4=CNC5=CC=CC=C45

Molecular Formula

C50H66I2N12O10S2

Molecular Weight

1313.07

References & Citations

[1]Tarasco E, et al. Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats. Endocrine. 2017 Oct;58 (1) :124-133.