IDE/Insulin Degrading Enzyme Mouse mAb
Insulin Degrading Enzyme (IDE) is a large zinc-binding protease of the M16A metalloprotease subfamily known to cleave multiple short polypeptides that vary considerably in sequence. IDE was first identified by its ability to degrade the B chain of the hormone insulin. This activity was observed over fifty years ago, though the enzyme specifically responsible for B chain cleavage was identified more recently.
Product Specifications
Background
Product Name Alternative
Abeta degrading protease, insulin degrading enzyme, Insulin protease, Insulinase, INSULYSIN
UniProt
P14735
Swiss Prot
P14735
Reactivity
Human
Immunogen
Synthetic Peptide
Clonality
Monoclonal
Source
Mouse
Applications
WB, IHC
Concentration
1mg/mL
Dilution
WB 1:1,000 IHC 1:200
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Molecular Weight
118kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
118kDa
Fragment
IgG1
Subcellular Location
Cell membrane, Cytoplasm, Membrane, Secreted
Other Product Names
Abeta degrading protease, insulin degrading enzyme, Insulin protease, Insulinase, INSULYSIN
Gene ID (Human)
3416
Available Sizes
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