CD21 Mouse mAb
CD21 also known as complement receptor 2 (CR2), C3d receptor or EBV receptor is a 140 kDa protein. CD21 is a glycosylated type I transmembrane protein consisting of an extracellular face of a series of 15 or 16 CCP domains. CD21 is the receptor for complement components C3d and iC3b as well as the Epstein-Barr virus (EBV) glycoprotein gp350/220. The soluble CD21 (sCD21) was shown to efficiently trigger CD23 signalling pathways in human monocytes. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, sCD21 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders.
Product Specifications
Background
Synonyms
C3DR, Complement C3d receptor, Complement receptor type 2, CR2, EBV receptor, Epstein Barr virus receptor, SLEB9
Gene ID
1380
UniProt
P20023
Cellular Locus
Membrane
Host
Mouse
Species Reactivity
Human,Rat,Mouse
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic Peptide
Clonality
Monoclonal
Isotype
IgG1
Source
Mouse
Applications
IHC
Validated Applications
IHC
Stability
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Concentration
1 mg/mL
Dilution
IHC 1:200
Molecular Weight
113kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/mAb/EM1060-1.pdf
Observed Molecular Weight
113 kDa
Subcellular Location
Membrane
Other Product Names
C3DR, Complement C3d receptor, Complement receptor type 2, CR2, EBV receptor, Epstein Barr virus receptor, SLEB9
Gene ID (Human)
1380
SwissProt (Human)
P20023
Available Sizes
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