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Lamin B1 Mouse mAb

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.

Product Specifications

Background

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.

Synonyms

ADLD, LMB1, LMNB1, MGC111419, OTTHUMP00000159218

Gene ID

4001

UniProt

P20700

Cellular Locus

Mitochondrion inner membrane

Host

Mouse

Species Reactivity

Human,Rat,Mouse

Reactivity

Human, Rat, Mouse

Immunogen

Recombinant Protein

Clonality

Monoclonal

Isotype

IgG1

Source

Mouse

Applications

WB, IP

Validated Applications

WB,IP

Stability

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Concentration

1 mg/mL

Dilution

WB 1:2,000-5,000 IP 1:200

Molecular Weight

68kDa

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/mAb/EM1035-1.pdf

Observed Molecular Weight

68 kDa

Subcellular Location

Mitochondrion inner membrane

Other Product Names

ADLD, LMB1, LMNB1, MGC111419, OTTHUMP00000159218

Gene ID (Human)

4001

SwissProt (Human)

P20700

Available Sizes

Curated Selection

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