CytoPak ActiveMax® Human DLL4 μBeads, premium grade (for cells, 5.5μm)

CytoPak ActiveMax® Human DLL4 μBeads, premium grade (for cells) are optimized for large-scale in vitro differentiation of induced pluripotent stem cells (iPSCs) in systems such as cellbags, or stirred-tank bioreactors. The beads functionally mimic thymic DLL4+ epithelial cells by engaging Notch receptors (e.g., Notch1/2) on hematopoietic stem/progenitor cells (HSPCs), thereby activating downstream Notch signaling pathways to drive lineage-specific differentiation. A representative application case is exemplified by ActiveMax® Human DLL4 μBeads, premium grade (for cells), which induce the differentiation of CD34+ hematopoietic stem cells into progenitor T cells lineage (proT cells), Natural Killer (NK) cells lineages etc. under in vitro conditions with the specialized culture media and cytokines supplementation. This product provides a powerful tool for developing stem cell-based immunotherapies. The dosage and performance of CytoPak ActiveMax® Human DLL4 μBeads, premium grade (for cells) vary with the differentiation of cell donor, culture media, cytokines supplementation, and target cell lineages etc. It is recommended to optimize the experiment parameters using small-size product (Cat. No. MBS-C013) prior to scaling up.

This product is supplied and shipped as sterile liquid solution with dry ice, please inquire the shipping cost. Upon receipt, store it immediately at -70°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: • -20˚C for 3 months. • -70°C for 24 months.