Cis-Urocanic acid

Cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM) . cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor[1].

Product Specifications

CAS Number

[7699-35-6]

Product Name Alternative

(Z) -Urocanic acid; cis-UCA

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cis-urocanic-acid.html

Purity

99.92

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C\C1=CN=CN1

Molecular Formula

C6H6N2O2

Molecular Weight

138.12

References & Citations

[1]Walterscheid JP, et al. Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor. Proc Natl Acad Sci U S A. 2006 Nov 14;103 (46) :17420-5.|[2]Viiri J, et al. Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro. Mol Vis. 2009 Sep 8;15:1799-805.