Sinigrin (hydrate)

Sinigrin (Allyl-glucosinolate) hydrate is an orally active glucosinolate found in cruciferous plants. Sinigrin hydrate possesses multiple activities such as anti-cancer, antibacterial, antifungal, anti-inflammatory, antioxidant, and inhibition of fat synthesis. Sinigrin hydrate can be used in the research of tumors, inflammatory, and metabolic diseases[1][2][3][4].

Product Specifications

CAS Number

[64550-88-5]

Product Name Alternative

Allyl-glucosinolate (hydrate) ; 2-Propenyl-glucosinolate (hydrate)

UNSPSC

12352005

Target

Akt; AMPK; Apoptosis; Bacterial; CDK; Fungal; Interleukin Related; mTOR; p38 MAPK; PI3K; PPAR; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sinigrin-hydrate.html

Purity

99.92

Solubility

H2O : ≥ 50 mg/mL

Smiles

O[C@@H]1[C@@H](O)[C@H](S/C(CC=C)=N/OS(=O)(O[K])=O)O[C@H](CO)[C@H]1O.O

Molecular Formula

C10H18KNO10S2

Molecular Weight

415.48

References & Citations

[1]Mazumder A, et, al. Sinigrin and Its Therapeutic Benefits. Molecules. 2016 Mar 29;21 (4) :416.|[2]Lee HW, et al. Inhibitory effect of sinigrin on adipocyte differentiation in 3T3-L1 cells: Involvement of AMPK and MAPK pathways. Biomed Pharmacother. 2018 Jun;102:670-680.|[3]Li S, et al. Sinigrin Impedes the Breast Cancer Cell Growth through the Inhibition of PI3K/AKT/mTOR Phosphorylation-Mediated Cell Cycle Arrest. J Environ Pathol Toxicol Oncol. 2022;41 (3) :33-43.|[4]Rama Satya Sri Kotipalli, et al. Sinigrin Attenuates the Dextran Sulfate Sodium-induced Colitis in Mice by Modulating the MAPK Pathway. Inflammation. 2023 Jun;46 (3) :787-807.