Alkannin

Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2) . Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL) . Alkannin acts as a potential anticancer agent[1].

Product Specifications

CAS Number

[23444-65-7]

UNSPSC

12352005

Target

Pyruvate Kinase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/alkannin-1.html

Solubility

10 mM in DMSO

Smiles

OC1=C(C=C(C2=C1C(C=CC2=O)=O)O)[C@H](C/C=C(C)\C)O

Molecular Formula

C16H16O5

Molecular Weight

288.30

References & Citations

[1]J Chen, et al. Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. Oncogene. 2011 Oct 20;30 (42) :4297-306.