Alkannin
Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2) . Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL) . Alkannin acts as a potential anticancer agent[1].
Product Specifications
CAS Number
[23444-65-7]
UNSPSC
12352005
Target
Pyruvate Kinase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/alkannin-1.html
Solubility
10 mM in DMSO
Smiles
OC1=C(C=C(C2=C1C(C=CC2=O)=O)O)[C@H](C/C=C(C)\C)O
Molecular Formula
C16H16O5
Molecular Weight
288.30
References & Citations
[1]J Chen, et al. Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. Oncogene. 2011 Oct 20;30 (42) :4297-306.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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