BMS-191095
BMS-191095 is a selective activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels. BMS-191095 inhibits human platelet aggregation by opening mitochondrial K (ATP) channels[1][2][3].
Product Specifications
CAS Number
166095-21-2
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/BMS-191095.html
Purity
98.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(O1)(C)[C@H](O)[C@@H](N(CC2=NC=CN2)C3=CC=C(Cl)C=C3)C4=C1C=CC(C#N)=C4
Molecular Formula
C22H21ClN4O2
Molecular Weight
408.88
References & Citations
[1]Katakam PV, et al. Diversity of mitochondria-dependent dilator mechanisms in vascular smooth muscle of cerebral arteries from normal and insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2014 Aug 15;307 (4) :H493-503.|[2]Cho MR, et al. BMS-191095, a cardioselective mitochondrial K (ATP) opener, inhibits human platelet aggregation by opening mitochondrial K (ATP) channels. Arch Pharm Res. 2005 Jan;28 (1) :61-7.|[3]Mayanagi K, et al. The mitochondrial K (ATP) channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2007 Feb;27 (2) :348-55.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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