RORγt inverse agonist 23
RORγt inverse agonist 23 is a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist.
Product Specifications
CAS Number
2230779-18-5
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rorγt-inverse-agonist-23.html
Purity
99.34
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC1C2=C(C=CC(S(N(C3=CC=C(CC)C=C3)C4CCC4)(=O)=O)=C2)OC(C5CCOCC5)C1
Molecular Formula
C26H33NO5S
Molecular Weight
471.61
References & Citations
[1]Chen L, et al. Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist. J Med Chem. 2021 Nov 11;64 (21) :16106-16131.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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