4-Chlorophenylguanidine (hydrochloride)

4-Chlorophenylguanidine hydrochloride is an urokinase-type plasminogen activator inhibitor. 4-Chlorophenylguanidine hydrochloride is a potent ASIC3 positive allosteric modulator and reverses the effects of ASIC3 desensitization. 4-Chlorophenylguanidine hydrochloride influences ASIC3 activity through directly activating the channel and increasing proton sensitivity. 4-Chlorophenylguanidine hydrochloride offers a chemical backbone for the design of new ASIC3 ligands to study ASIC3 in vivo[1].

Product Specifications

CAS Number

[14279-91-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-chlorophenylguanidine-hydrochloride.html

Purity

99.07

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NC(NC1=CC=C(Cl)C=C1)=N.[H]Cl

Molecular Formula

C7H9Cl2N3

Molecular Weight

206.08

Precautions

H302, H315, H319, H335

References & Citations

[1]Amruta S Agharkar, et al. 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J Pharmacol Sci. 2017 Mar;133 (3) :184-186.