KDU691

KDU691, an imidazopyrazine with potent anti-parasitic activity against blood stage schizonts, gametocytes and liver stages, is a Plasmodium PI4K inhibitor. KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites[1].

Product Specifications

CAS Number

[1513879-19-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Parasite; PI4K

Type

Reference compound

Related Pathways

Anti-infection; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/KDU691.html

Purity

99.43

Solubility

DMSO : 150 mg/mL (ultrasonic; warming)

Smiles

ClC1=CC=C(N(C(C2=CN3C(C=N2)=NC=C3C4=CC=C(C(NC)=O)C=C4)=O)C)C=C1

Molecular Formula

C22H18ClN5O2

Molecular Weight

419.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Dembele L, et al. The Plasmodium PI (4) K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites. Sci Rep. 2017;7 (1) :2325. Published 2017 May 24.|[2]Zeeman AM, et al. PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites. Antimicrob Agents Chemother. 2016;60 (5) :2858-2863. Published 2016 Apr 22.