Antiproliferative agent-14
Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle[1].
Product Specifications
CAS Number
1885900-35-5
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antiproliferative-agent-14.html
Concentration
10mM
Purity
98.76
Solubility
DMSO : ≥ 100 mg/mL
Smiles
COC1=CC=C(C=C1)CNC2=C(N=C3C=CC(F)=CN32)C4=C(C=CC=C4)O
Molecular Formula
C21H18FN3O2
Molecular Weight
363.38
References & Citations
[1]An W, et al. Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents. Eur J Med Chem. 2016 Apr 13;112:367-372.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![2-[[6-Amino-5-(4-bromophenyl)-4-pyrimidinyl]oxy]-ethanol](https://cdn.genprice.uk/products/572/1604481132460/imageurl/trc-a594865-5mg.webp)
TRC-A594865-5MG 5 mg
2-[[6-Amino-5-(4-bromophenyl)-4-pyrimidinyl]oxy]-ethanol
Sign In for Pricing
View Details 
BNUB2250-500 1x 500 µL
Squamous Cell Carcinoma Antigen 1 (CPTC-SERPINB3-2), 0.2mg/mL
Sign In for Pricing
View Details 
BNC942272-100 1x 100 µL
PDZ and LIM Domain 1 (CPTC-PDLIM1-1), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
